The most common negative responses bring about discontinuation of clonidine hydrochloride extended-release tablets monotherapy treated clients were from somnolence/sedation (5 %) and tiredness (4 %).

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Taking clonidine with other medicines that make you slow or sleepy your breathing could increase these impacts.

Advise clients to avoid use with alcoholic beverages.

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Ask your physician just before taking this medication with a resting pill, narcotic discomfort medication, muscle mass relaxer, or medicine for stress and anxiety, depression, or seizures.